For those who prefer and dare to a bit different and not go with the German norm, the LS is the best you can get outside of Germany. Audi A8, BMW 7 series and Mercedes S Class all fall into the same league. Whether its in the same Class, thats a different topic. I went for a GS300 over a Merc E and BMW 5, and have never regretted it.
Some would compare a Lexus to an Infiniti, but I personally wouldnt.