Dear Imran Bhai.
Salam
U can do in one go if both driver are experienced.
Road condition from lhr to ryk is good.
And ryk to hyd its excellent road newly built road.
2 year before there were diversion after every km single road due to construction.
Please note when u travel from khanewal to lodhran so do not take khanewal lodhran road because ita very bad road. Although its short but it will more time then other route.
So after i cross khanewal go to multan and then to lodhran its excellent built road.
After u cross khanewal then after some distance u will see M4 motorway. U will bypass multan.
M4 is a part of khi lhr motorway. And this patch M4 is named as multan fsl motorway.
Or then u will take left turn towatd gopolpur to lodhran and reach lodhran and then continue ur journey.
Note: stick to double road do jot leave it. Stick to N5.
Now come the timmings.
U should leave lhr at 12 pm and reach sadiqabad at 9am or 10 am .
Because at night there is less traffic so u will maintain the speed.
At sadiqabad change the driver have breakfast.
Have some rest and leave from sadiqabad at 11 am.
Then hig the paddle towards khi.
U will reach ubaro in 40 mins. Then ghotki in then pannu aqil then sukkuru will sukkur till 3 pm.
Then have lunch and offer namaz and levave for khim it will take 6 hr to reach khi.
U will reavh till hyd at 7 or 8 pm.
So in end of may sunset wilm be around 730.
Once u reach hyd so u r out of danger zone.
Then have hala naka karahi;-) at hyd.
Or leave for khi.
Note hyd to khi road in construction.
Road is double but speed is reduced. So it will take around 2:30 min .
So at 10pm u will be in khi inshallah.
For way consult google maps.
Do not make the way on mobile maps because it do not have point option and it will divert u to jndus highway larkana dadu shikarpur side. Where u will be someones shikar.
So make point as follow.
Lhr to khanewal.
Khanewal to m4
Then to lodhran
Then to ubaro
Then to sukkur
Then khi.