I will try to answer these questions in best way possible.
Personally I take risk on travelling such route. Risk factor is 100% when you leave Shikarpur till Quetta.
Anything can happen. Just search for it on google and you will come to know 1000's of killings/kidnappings etc in these areas. But I have to take this risk to get to job once an year when I get vacations... I have other choice of coming to Hyderabad via Quetta->Khuzdar->Karachi route but it again is equally risky road with no city for 100 kms when you leave BELA. The best way is to come via by AIR to Quetta... which I take when coming for short period of week or two.
This is my first time taking an SUV before that I have always used my Honda City...
Till now I have been to Quetta-Hyderabad totalling 20 times.. 18 on Honda City and 2 on my SUV.