remove the battery negative terminal and connect your digital multimeter between the battery and the negative cable, set your DVOM to measure amps.
use a 7.5 or 8 amp inline fuse to protect the DVOM, check the amps with everything off, it should be a very small amount if your car is EFI and has a radio too. something about 10 to 20 milliamps. If you see 1 amp or more you have a problem, if the fuse blows you have a draw of more than the fuse you used.
Start by disabling certain circuits like the aftermarket security system, you will find your problem as soon as the draw drops by removing the culprit.