As I know you can visit Khairpur, Sukker & Larkana for visit some historical places
In Khairpur you can visit 1- Kot Diji Fort 2- Mehrano Wildlife (Need permission) 3- Faiz Mahal, 4- Chundko Desert (Need 4x4)
In Sukker you can visit 1- Sattiyon jo astano (Seven sisters graves) 2- Lansdowne bridge, 3- Sukker Barrage
In Larkana 1- Moinjo Daro, 2- Garhi Khuda bux (Bhutto family tomb)
You can also visit shrine of Sachal Sar Mast Qalandar near gambat
