@ nickoakey
bhai there r many routes now its totally upto u which one u take :d
the shortest route for ISB is Karachi, Hyderabad, Sehwan Sharif, Dadu, Larkana, Rajan pur, Panjnad, Muzaffar garh, Chowk Azam, Mianwali, talagang, fatehjang n then Islamabad
u can take another route Karachi, Hyderabad, Sehwan, Dadu, Larkana, Panjnad, Muzaffar garh , Multan, khanewal , Shaiwal, Lahore n then Islamabad 
bhai there r many routes:D kahan tak suno ge kahan tak sunaoun 
but the route i told u in my previous post is safest n the best (Y)