Dear Farhan Ali,
From Lahore to Sadiqabad (sindh Punjab border) the road condition is good, from Ubaro to Ghotki is not as good, and from Ghotki to Rohri is good, from Rohri to More is also good, from Moro to Hyderabad is also good but few pieces are under construction, and finally from Hyderabad to Karachi is total under construction for motorway, Over all not much difficult.