I see many queries regarding route planning and road condition update, then why not sum-up all in one platform for better guidance and information? 
Lets come to my query, regarding Karachi to Islamabad journey, I usually took this route and found it convenient with less traffic;
Karachi - Multan - Jhang - Pindi Bhattian - Islamabad.
But now I'm thinking to take another route for change, which is;
Karachi - Taranda - Alipur - Muzzafargarh - Chowk Azam - Mianwali - Balkasar Interchange - Islamabad.
Is this route better in condition then above? and how is traffic there? Anyone who can guide me to go for change or be stick with first route? 
Secondly, I plan to leave Karachi around 11 PM, but I heard N-5 in Sindh is still under construction, should I take alternate Mehran Highway (Nawabshah - Daur - Khairpur)? I can't make my mind as travelling in Sindh is something which always make tick tock in heads so can't decide whether stay and face diversions on N-5 or take Mehran Highway.
(P.S. I'll be travelling with family and kids, with a night stay plan in Multan or Muzaffargarh.)
@Libra