Brother We used three different Route for Layyah from Sukkur to onward.
1st one On reach at Sukkur U should take N65 Hwy for Shikarpur then take righ turn on N55 ( Indus Hwy) Kandhkot- Kashmor then enter in Punjab Rajanpur then Jampur and DG khan and go toward Taunsa Barrage and Kot Addu Deria Deen Panah and Kot Sultan at end Layyah.
In this Route Sukkar CNG available but in Shikarpur to Rajanpur No CNG Available .
In Layyah there are two CNG station Suitable Kot Addu Road.
Problem on this route that " This totally Un-safe route in Night and 99% Robbery chances on this route" This shorter as compare to two Other but not for family.
Second Route for Layyah from Sukkar onward is as follow:
Sukkar to take N-5 for Ghotki - Kot Sabzal (Punjab Boarder) Sadiqabad - Wahan Sheikh and Ahmedpur East
From Ahmedpur East there further two route to Layyah
One is Uch Sharif Punjnad Headwork Alipur Muzaffargarh Kot Addu Deria Deen Panah and Enter in Layyah.
CNG is Avaiable in Uch Sharif , Khan Garh, Muzaffargarh, and Kot Addu. in Alipur no CNG.
Second Ahmedpur East to Bahawalpur -Loderan Multan then go to Muzaffargarh and Chowk Munda (Chowk Sarwar Shaheed) Chowk Azam and Layyah.
CNG not Available Chowk Munda, Chowk Azam. It is also longer then 1st one.
I perfered Sukkar - Kot Sabzal- Sadiqabad Ahmedpur East, Uch Sharif Punjand Headwork Alipur Shehr Sultan Khangarh Muzaffargarh Kot Addu , Deria deen Panah , Kot Sultan And Layyah. Not much busy Roads CNG is Avaiable on Route.
Also an other route availability there onward Alipur , Alipur to Chowk permat (Chowk Nadir ) Jotai , Shah Jamal, Chowk Karimdad Qureshi , Qasaba Gujrat, Sanawan, Kot Addu, Deria Deen Panah and Kot Sultan and Layyah.
I know these routes because in Last Floor-2010 we traveled through these routes.