Open the radiator screw first, then open the lower hose engine side having the thermostate (going from lower part of radiator to the engine block) the hose clip is a bit tricky to open. After that, open the upper hose radiator side (going from upper radiator to the engine). Use air blower to flush the remaining coolant. Close the system and use distilled water to flush.
(When reinstalling the thermostate, there's a small hole/knob on it, make sure to keep the knob on the upper side. Also, properly attach the gaskit on the thermostate)
After that, use the new coolant and do air removal procedure. Continued...