Single driver fr such long trip not recommended at all.... There has to be 1 more driver to share the load of driving... If not, then you need to make more stop overs and rest more...10 hrs of constant drive for 1 driver is max for an alert driving, after this drive needs rest\nap\sleep...i have been travelling alot between khi, sukkur, Multan
Mechanically:
Change air filter, oil and oil filter before leaving
Make sure cooling system is perfect with thermostat and auto fan, and coolant.
Check brakes
Keep a small tool kit
Extra timing belt (old car)
Perfect spare tyre
Keep speeds 100 only to put less strain on engine for longer times.
Take 15 mins stop every 3\4 hrs to stretch ur legs