They will be comparatively expensive. And if some tile breaks, then replacement cost will also be higher.
2ndly, consider 2'x2' single tile and matrix of 2'x2' containing 16 tiles of 6"x6" each. If anyone from these breaks, then they might be 2~3 tiles (may be even 1) which will have to be replaced, so cost will be less, but if one single tile of 2'x2' breaks, then cost will be quite high.
Rest, Tajammal Bhai can guide better and further.