amplifier gain knob is actually there to match the output voltage of the pre with the input of amp. amps usually clip on higher setting and this gain knob starts from a high volt to lower volt setting. so for pres with higher volt outs, u dont need to turn the gain up that much and consequently u get less or no distortion.
in simple words, u will have to set the gain twice as high for a pre with 2 volt out as compared to one with 4 volts out. and lesser gain u have to open, the better.
so yeah, higher volt out pre are preferred if u require sq