nope the tyres won't touch the fenders thats for sure coz i was using maxspeed lowering on my 7th gen. civic with 195/65/R15 tyres and i didn't had the slightest of problems. but bro as u mentioned u have 45 profile tyres with 16 inch rims, so don't u think it is bit too low profile, i mean 45 profile normally we see with 17 inch rims and i also used maxspeed springs on my 8th gen. civic aswell with 205/60R16 tyres and again didn't had any problems. 
the ride obviously gets harder and it shud be or else  won't enjoy the drive but i think in ur case u will feel the pain abit more with 45 profile tyres with 16'' rims. btw im going to share a link of my thread with u where u will come across endless pictures of my lowered 04 civic 